Healthy bone through the microbiome


Design and development of a novel food supplement for osteoporosis based on gut microbiome mechanisms. (OSTEOME)

OSTEOME is a research proposal that was created through the collaboration of three research organizations (National Foundation for Research, Laboratory for Research on Musculoskeletal Disorders, and Skeletal Health Society – Petalouda) and two private companies (Cloudpharm and Life Lnb). The program was approved in 2019 as an innovative Greek research project from which a product with significant social and economic impact will manifest. The project was approved and is implemented under the call RESEARCH – CREATE – INNOVATE,  co‐financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation (project code: Τ2EDK-03847).

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Bone metabolism and microbiome

The aim of the project OSTEOME is to design and develop a novel dietary supplement for osteoporosis, activating the intestinal microbiome. At the same time companion biomarkers will be studied related to the efficacy and tolerability of the new supplement. The selection of flavonoids will take place through in vitro and in silico studies focusing on their interaction with pathways that regulate the activity of osteoclasts and osteoblasts. The efficacy and tolerability of the dietary supplement will be evaluated through a randomized clinical intervention.



Osteoporosis is a chronic bone disorder characterized by reduced bone density and increased susceptibility to fractures. It often affects postmenopausal women and older individuals, but it can impact other age groups as well. This condition poses a significant threat to productivity and quality of life, as it is associated with an elevated risk of osteoporotic fractures, morbidity, and mortality. Despite various therapeutic approaches, the effectiveness of these treatments varies among patients, highlighting the need for more personalized strategies.

Simultaneously, the gut microbiome, the community of microorganisms residing in our digestive system, has emerged as a vital factor in maintaining overall health. It influences metabolism, the immune system, and human well-being in general. Recent research has shown that the gut microbiome affects bone metabolism through various pathways.

Prebiotics for Osteoporosis? Indeed, they are a more critical ally! Prebiotics, such as fructooligosaccharides and galactooligosaccharides, have been demonstrated to enhance calcium absorption, improve bone remodeling, and increase bone density. Additionally, researchers are investigating the role of polyphenols, such as epigallocatechin found in green tea, in bone metabolism. These advancements open up new possibilities for more effective approaches to maintaining bone health by regulating the gut microbiome. Want to learn more?


The proposed project results from the collaboration of three complementary research bodies, the Musculoskeletal Diseases Research Laboratory “Th. Garofalidis ” of the Medical School of EKPA, the Institute of Chemical Biology of the National Research Foundation, the  Butterfly Bone Health Society and two Greek companies of CLOUDPHARM and LIFELNB.


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