Participation in the 15th Annual Skeletal Health Conference

On October 15th 2022, the «Butterfly» Bone Health Society organized the 15th annual Skeletal Health Conference at Divani Caravel Hotel. OSTEOME‘s representers were the coordinator of the project Associate Professor Panagiotis Zoumpoulakis, the Scientific Officer Professor Efstathios Chronopoulos, the head of the clinical intervention Endocrinologist George Trovas and the President of the «Butterfly» Bone Health Society Memi Tsekoura. The research project OSTEOME, was presented at the Open Day while the attended audience was informed about the role of the microbiome in osteopenia and the clinical study of the project. The event was held in the presence of the Regional Governor of Attica and President of the Athens Medical Association Mr. George Patoulis.

Participation in Beyond Expo 2022

CLOUDPHARM‘s project team participated in the BEYOND Innovation and Technology Exhibition, which took place from 29 September 2022 until 1 October 2022, at Thessaloniki. During the exhibition there was an opportunity to present the OSTEOME project and the research results so far to other researchers, entrepreneurs and the attended audience.

Effects of Non-Polar Dietary and Endogenous Lipids on Gut Microbiota Alterations: The Role of Lipidomics

Advances in sequencing technologies over the past 15 years have led to a substantially greater appreciation of the importance of the gut microbiome to the health of the host. Recent outcomes indicate that aspects of nutrition, especially lipids (exogenous or endogenous), can influence the gut microbiota composition and consequently, play an important role in the metabolic health of the host. This review firstly summarizes the general background regarding the interactions between important non-polar dietary or amphoteric endogenous lipids and gut microbiota. In addition, the present status of lipidomics in current clinical interventions as well as their strengths and limitations are also presented.

Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis

The human microbiota functions at the interface between diet, medication-use, lifestyle, host immune development and health. This paper summarizes the content, discussion and conclusions of a workshop held by the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society in October, 2020. It provide a detailed review of the literature examining the relationship between the microbiota and bone health in animal models and in humans, as well as formulating the agenda for key research priorities required to advance this field.

Hesperidin Promotes Osteogenesis and Modulates Collagen Matrix Organization and Mineralization In Vitro and In Vivo

This study evaluated the direct effect of a phytochemical, hesperidin, on pre-osteoblast cell function as well as osteogenesis and collagen matrix quality, as there is little known about hesperidin’s influence in mineralized tissue formation and regeneration. The findings show that hesperidin has a modulatory role in mineralized tissue formation via not only osteoblast cell differentiation but also matrix organization and matrix-to-mineral ratio and could be a potential adjunct in regenerative bone therapies.

Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. This review article focuses on osteoblasts as well as summarizes the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation.

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development. The nutrient components, inflammatory factors, and hormone environment play important roles in bone metabolism. Recently, intestinal microbiota has been found to influence bone metabolism via influencing the host metabolism, immune function, and hormone secretion. This review reports the effect of intestinal microbiota on bone metabolism through the above three aspects, which may provide new ideas and targets for the clinical treatment of osteoporosis.

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Gut microbiome and osteoporosis

Osteoporosis (OP) is a chronic metabolic bone disease characterized by the decrease of bone tissue per unit volume under the combined action of genetic and environmental factors, which leads to the decrease of bone strength, makes the bone brittle, and raises the possibility of bone fracture. However, the exact mechanism that determines the progression of OP remains to be underlined. There are hundreds of trillions of symbiotic bacteria living in the human gut, which have a mutually beneficial symbiotic relationship with the human body that helps to maintain human health. With the development of modern high-throughput sequencing (HTS) platforms, there has been growing evidence that the gut microbiome may play an important role in the programming of bone metabolism. In the present review, we discuss the potential mechanisms of the gut microbiome in the development of OP, such as alterations of bone metabolism, bone mineral absorption, and immune regulation. The potential of gut microbiome-targeted strategies in the prevention and treatment of OP was also evaluated.